Posted by Staff
Clinical Trials
Wednesday, March 27th, 2013
Diabetes Care: December 13, 2012
OBJECTIVE Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing cardiovascular disease, largely as a result of defective production of cardioprotective nitric oxide and a concomitant rise in oxidative stress. Dietary interventions that could reverse this trend would be extremely beneficial. Here we investigated whether dietary n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation positively affected platelet nitroso-redox imbalance.
RESEARCH DESIGN AND METHODS We randomized hypertensive T2DM patients (T2DM HT; n = 22) and age-and-sex matched hypertensive study participants without diabetes (HT alone; n = 23) in a double-blind, crossover fashion to receive 8 weeks of n-3 PUFAs (1.8 g eicosapentaenoic acid and 1.5 g docosahexaenoic acid) or identical olive oil capsules (placebo), with an intervening 8-week washout period. Read more
Posted by Staff
Clinical Trials
Wednesday, March 27th, 2013
Diabetes Care: November 27, 2012
OBJECTIVE Current guidelines for intensive treatment of type 1 diabetes base the mealtime insulin bolus calculation exclusively on carbohydrate counting. There is strong evidence that free fatty acids impair insulin sensitivity. We hypothesized that patients with type 1 diabetes would require more insulin coverage for higher-fat meals than lower-fat meals with identical carbohydrate content.
RESEARCH DESIGN AND METHODS We used a crossover design comparing two 18-h periods of closed-loop glucose control after high-fat (HF) dinner compared with low-fat (LF) dinner. Each dinner had identical carbohydrate and protein content, but different fat content (60 vs. 10 g). Read more
Posted by Staff
Clinical Trials
Wednesday, March 27th, 2013
Diabetes Care: November 19, 2012
OBJECTIVE Reliability of continuous glucose monitoring (CGM) sensors is key in several applications. In this work we demonstrate that real-time algorithms can render CGM sensors smarter by reducing their uncertainty and inaccuracy and improving their ability to alert for hypo- and hyperglycemic events.
RESEARCH DESIGN AND METHODS The smart CGM (sCGM) sensor concept consists of a commercial CGM sensor whose output enters three software modules, able to work in real time, for denoising, enhancement, and prediction. Read more
Posted by Staff
News
Wednesday, March 20th, 2013
FDA: March 14, 2013
The U.S. Food and Drug Administration (FDA) is evaluating unpublished new findings by a group of academic researchers that suggest an increased risk of pancreatitis, or inflammation of the pancreas, and pre-cancerous cellular changes called pancreatic duct metaplasia in patients with type 2 diabetes treated with a class of drugs called incretin mimetics. These findings were based on examination of a small number of pancreatic tissue specimens taken from patients after they died from unspecified causes. FDA has asked the researchers to provide the methodology used to collect and study these specimens and to provide the tissue samples so the Agency can further investigate potential pancreatic toxicity associated with the incretin mime tics. Read more
Posted by Staff
News
Wednesday, March 20th, 2013
Laredo Sun:March 14, 2013
The bad news for Laredoans is that diabetes is progressing strongly among the population. The good news is that the Laredo Health Department has a very efficient program that prevents and controls diabetes to those who already have it. Health authorities announced that next March 27 a new cycle of the “Viviendo Mejor” will begin with the offering of free classes people who want to learn how to control or prevent diabetes. Read more
Posted by Staff
News
Wednesday, March 20th, 2013
ADA Diabetes: March 14, 2013
Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in twenty-two morbidly obese patients before and six months after bariatric surgery. Seven healthy subjects served as controls. Brain glucose metabolism was measured twice per imaging session: with and without insulin stimulation (hyperinsulinemic euglycemic clamp) using [18F]FDG scanning. Read more
Posted by Staff
News
Wednesday, March 20th, 2013
Diabetes Care: March 14, 2013
OBJECTIVES To determine the correlates of the “metabolically healthy obese” (MHO) phenotype and the longitudinal risks of diabetes and cardiovascular disease (CVD)/stroke associated with this phenotype.
RESEARCH DESIGN AND METHODS The North West Adelaide Health Study is a prospective cohort study of 4,056 randomly selected adults aged ≥18 years. Participants free of CVD/stroke and not underweight (n = 3,743) were stratified by BMI categories and metabolic risk, defined as having two or more International Diabetes Federation metabolic syndrome criteria, excluding waist circumference. Read more
