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Recruitment strategies and yields for the Pathobiology of Prediabetes in a Biracial Cohort: a prospective natural history study of incident dysglycemia

BMC Medical Research Methodology: May 10, 2013

Background

The Pathobiology of Prediabetes in A Biracial Cohort study is a prospective evaluation of the transition from normal to impaired glucose regulation among African American and Caucasian adults with parental type 2 diabetes. This report describes recruitment strategies and relative yields for the 376 enrolled subjects.

Methods

Recruitment occurred over 3.4 years, with clinical and metabolic assessments during 2.1-5.5 years of quarterly follow-up. The major recruitment sources were advertisements, community outreach, and clinical facilities. Advertisements included newspaper, television, radio, Internet, distributed brochures, utility bill inserts, and direct mailing. Community outreach included screening events during religious gatherings and health fairs, and referral by friends and families. The category of clinical facilities covered all subjects referred by health workers or recruited through area clinics and hospitals. Read more

Finding Wisdom from the Ancestors

The Portland Observer: May 7, 2013

In an effort to reverse Type 2 diabetes among tribal populations, Natives call for a return to an ancestral plant-based diet.

Marc Anderson, 60, a descendent of Oklahoma Seminole Chief Billy Bowlegs, didn’t realize how bad the diet on his family’s reservation had become until a trip back home left him with a feeling of culture shock.

“The food was all fast food,” said Anderson, an environmental engineer living in Tualatin who has worked with tribal government for 16 years. Not even the nearby Indian Casino had vegetarian options. “I bought a watermelon at Walmart,” he joked, though the revelation he left home with was serious.

The average longevity of Tribal members is only 60-years-old, Anderson said, in large part due to diabetes and associated ailments, obesity and poor diet.  Anderson’s father and both grandmothers had diabetes, and now he is among those at risk of the disease. Read more

Perceptions of Barriers in Managing Diabetes

The Diabetes Educator May 2, 2013

Purpose Hispanics show poorer self-management of type 2 diabetes than non-Hispanic whites. Although previous studies have reported socioeconomic and cultural barriers to diabetes self-management by Hispanics, little is known about perceived barriers to diabetes self-management from the perspectives of both Hispanics and their family members. The purpose of the study was to explore perceived barriers among Hispanic immigrants with diabetes and their family members. Read more

Obesity and the Food Environment: Income and Ethnicity Differences Among People With Diabetes

Diabetes Care May 1, 2013

OBJECTIVES It is unknown whether any association between neighborhood food environment and obesity varies according to individual income and/or race/ethnicity. The objectives of this study were to test whether there was an association between food environments and obesity among adults with diabetes and whether this relationship differed according to individual income or race/ethnicity.

RESEARCH DESIGN AND METHODS Subjects (n = 16,057) were participants in the Diabetes Study of Northern California survey. Read more

Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients

Diabetes Care May 1, 2013

OBJECTIVE Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of mortality after diabetes diagnosis for South Asian and Chinese patients, compared with European patients. Read more

Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants with Type 2 Diabetes Mellitus in American Indians

Diabetes April 29, 2013

Parent-of-origin effects were observed in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499) and KCNQ1 (rs2237892, rs231362). We analyzed parent-of-origin effects for these variants, along with two others in KCNQ1 identified in previous genome-wide association studies (rs2237895, rs2299620), in 7351 Pima Indians from 4549 nuclear families; 34% of participants had diabetes. Read more

Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes

Diabetes Care April 25, 2013

OBJECTIVES Evaluate ITCA 650, a continuous subcutaneous miniature osmotic pump delivery system of exenatide versus twice-daily exenatide injections (Ex-BID) in subjects with type 2 diabetes.

RESEARCH DESIGN AND METHODS Randomized, two-stage, 24-week, open-label, phase 2 study in type 2 diabetes inadequately controlled with metformin. Stage I: 155 subjects were randomized to 20 or 40 μg/day of ITCA 650 or Ex-BID 5→10 μg. Stage II: 131 subjects were rerandomized to 20, 40, 60, or 80 μg/day of ITCA 650. Change from baseline for HbA1c, weight, and fasting plasma glucose were evaluated at weeks 12 and 24. Read more

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