Type 2 Diabetes and 10-Year Risk of Dementia and Cognitive Impairment Among Older Mexican Americans

Diabetes Care: March 20, 2013

OBJECTIVE Type 2 diabetes has been linked with increased risk of dementia and cognitive impairment among older adults and with premature mortality in young and middle-aged adults. No studies have evaluated the association between diabetes and dementia among Mexican Americans, a population with a high burden of diabetes. We evaluated the association of diabetes with incidence of dementia and cognitive impairment without dementia (CIND) among older Mexican Americans while accounting for competing risk from death. Read more

Influence of Race on the Management of Lower Extremity Ischemia

JAMA Surgery: March 20, 2013

Importance  Among patients presenting with critical lower extremity ischemia, it has been previously documented that white individuals are more likely to undergo revascularization than nonwhite individuals, with the disparity largely attributed to differences in resources and access to care.

Objective  To investigate the amputation disparity between white and nonwhite patients with critical lower extremity ischemia in more detail using a larger data set than previous studies, with a focus on the role of confounding factors such as access and hospital resources. Read more

Arsenic Exposure and Incidence of Type 2 Diabetes in Southwestern American Indians

Am. J. Epidemiology: March 15, 2013

Association of urinary arsenic concentration with incident diabetes was examined in American Indians from Arizona who have a high prevalence of type 2 diabetes and were screened for diabetes between 1982 and 2007. The population resides where drinking water contains arsenic at concentrations above federally recommended limits. A total of 150 nondiabetic subjects aged ≥25 years who subsequently developed type 2 diabetes were matched by year of examination and sex to 150 controls who remained nondiabetic for ≥10 years. Read more

Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children

Diabetes Care: October 23, 2012

OBJECTIVE The Old Order Amish (OOA) is a conservative Christian sect of European origin living in Pennsylvania. Diabetes is rare in adult OOA despite a mean BMI rivaling that in the general U.S. non-Hispanic white population. The current study examines childhood factors that may contribute to the low prevalence of diabetes in the OOA by comparing OOA children aged 8–19 years with National Health and Nutrition Examination Survey (NHANES) data and children from Maryland’s Eastern Shore (ES), a nearby, non-Amish, rural community. We hypothesized that pediatric overweight is less common in OOA children, that physical activity (PA) and BMI are inversely correlated, and that OOA children are more physically active than ES children. Read more

Over 8,200 Clinical Trials of Medicines Conducted by Texas Research Institutions Since 1999

Phrma: March 25, 2013

The report findings show the state’s clinical tests of new medicines have been beneficial to patients, the advancement of science and the economy.

“Improving health is a shared goal of biopharmaceutical companies and state medical schools, hospitals and clinical research facilities. Through clinical trials, they are not only helping advance science and improve patient care, but also strengthening Texas’ economy,” said Jeffrey Bond, Senior Vice President, PhRMA. “When you consider that clinical trials account for 45 to 75 percent of the average $1.2 billion needed to develop a new medicine, there is greater appreciation for not only the health benefits generated from clinical trials, but also the economic benefits to the state.”

Biopharmaceutical research companies are an important source of jobs, tax revenue and research spending in Texas. The Texas Emerging Technology Fund (TETF) has invested over $130 million in pharmaceutical-related startups since 2005. That public investment in research and development is supported by the state’s vast network of public universities and health-related institutions. In 2010, Texas public institutions of higher education invested more than $2.5 billion on medical and life sciences research, accounting for 61 percent of all higher education R&D expenditures in the state. Read more

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes

Diabetes Care: March 20, 2013

Large Pre- and Postexercise Rapid-Acting Insulin Reductions Preserves Glycemia and Prevents Early- but Not Late-Onset Hypoglycemia in Patients With Type 1 Diabetes

Diabetes Care: March 20, 2013