Stories written by Staff

AUTONOMY: The First Randomized Trial Comparing Two Patient-Driven Approaches to Initiate and Titrate Prandial Insulin Lispro in Type 2 Diabetes

Diabetes Care August 2014

OBJECTIVE To compare two self-titration algorithms for initiating and escalating prandial insulin lispro in patients with type 2 diabetes inadequately controlled on basal insulin.

RESEARCH DESIGN AND METHODS The trial was designed as two independent, multinational, parallel, open-label studies (A and B), identical in design, to provide substantial evidence of efficacy and safety in endocrine and generalist settings. Subjects were 18–85 years old (study A: N = 528; study B: N = 578), on basal insulin plus oral antidiabetic drugs for ≥3 months, and had an HbA1c 7.0% to ≤12.0% (>53.0 to ≤107.7 mmol/mol). Once optimized on insulin glargine, subjects were randomized to one of two self-titration algorithm groups adjusting lispro either every day (Q1D) or every 3 days (Q3D) for 24 weeks. The primary outcome was the change in HbA1c from baseline. The primary and secondary objectives were evaluated for the overall population and subjects ≥65 years old. Read More

Effectiveness and Safety of Patient Activation Interventions for Adults with Type 2 Diabetes: Systematic Review, Meta-Analysis, and Meta-regression

Springer: Journal of General Internal Medicine – August 2014

BACKGROUND

Patient activation interventions (PAIs) engage patients in care by promoting increased knowledge, confidence, and/or skills for disease self-management. However, little is known about the impact of these interventions on a wide range of outcomes for adults with type 2 diabetes (DM2), or which of these interventions, if any, have the greatest impact on glycemic control.

METHODS

Electronic databases were searched from inception through November 2011. Of 16,290 citations, two independent reviewers identified 138 randomized trials comparing PAIs to usual care/control groups in adults with DM2 that reported intermediate or long-term outcomes or harms. For meta-analyses of continuous outcomes, we used a random-effects model to derive pooled weighted mean differences (WMD). Read More

Effect of Diabetes Mellitus Type 2 on Salivary Glucose – A Systematic Review and Meta-Analysis of Observational Studies

PLOS: July 15, 2014

Background

Early screening of type 2 diabetes mellitus (DM) is essential for improved prognosis and effective delay of clinical complications. However, testing for high glycemia often requires invasive and painful blood testing, limiting its large-scale applicability. We have combined new, unpublished data with published data comparing salivary glucose levels in type 2 DM patients and controls and/or looked at the correlation between salivary glucose and glycemia/HbA1c to systematically review the effectiveness of salivary glucose to estimate glycemia and HbA1c. We further discuss salivary glucose as a biomarker for large-scale screening of diabetes or developing type 2 DM.Read more

Lifesaving lessons: Diabetes self-management education helps save lives in South Texas

News.tamhsc.edu: July 14, 2014

Texas is expected to have nearly eight million residents suffering from diabetes by the year 2040, according to a 2010 report released by the Texas Health Institute, State Demographer’s Office and Methodist Healthcare Ministries of South Texas.  In South Texas, nearly one in four (20%) adults has been diagnosed with diabetes, according to the Texas Department of State Health Services, but many more have it and don’t know it. And in the Texas Coastal Bend, more than 31% of adults are overweight and 42.3% are obese. That means nearly three quarters of the population in the Coastal Bend is at increased risk for developing type 2 diabetes.

In response to this epidemic, the Texas A&M Health Science Center Coastal Bend Health Education Center (CBHEC) Diabetes Education program provides resources on how to prevent and control diabetes for residents and health professionals of the Coastal Bend – the Southern region of Texas curving around the Gulf of Mexico from the large port cities of Corpus Christi to the southern tip at South Padre. Read More

Prevalence of Diabetes and Associated Obesity in Pennsylvania Adults, 1995–2010

CDC: 7/3/14

Abstract

Introduction
This study examined trends in the prevalence and sociodemographic distributions of diabetes and the associations of diabetes with obesity over time in adult Pennsylvanians from 1995 through 2010.

Methods
We used Behavioral Risk Factor Surveillance Survey data collected from 1995 through 2010. Diabetes prevalence was assessed by self-report of physician diagnosis. Obesity was assessed by body mass index computed from self-report of height and weight. State-level data for diabetes and associated obesity prevalence from 1995 through 2010 were collected for each year. Data on sociodemographic factors (age, sex, race, income, education) and 1 known disease risk factor (obesity) were also collected. Logistic regression modeling was used to examine associations between diabetes, sociodemographic factors, and obesity. Read more

Decade-Long Trends in Mortality Among Patients With and Without Diabetes Mellitus at a Major Academic Medical Center

JAMA: July 2014

The prevalence of diabetes mellitus has risen markedly over the past decade and is projected to increase substantially.1 More than 20% of hospitalized patients are estimated to have diabetes,2 and individuals with diabetes have historically experienced higher inpatient mortality than individuals without diabetes.3 Over the past decade, evidence from large clinical trials has prompted recommendations for tighter inpatient and outpatient glucose control, as well as more stringent blood pressure and lipid management, to improve outcomes for patients with diabetes.4– 6 It is unclear whether the mortality impact of diabetes has changed as a consequence. Read More

Update on Health Literacy and Diabetes

The Diabetes Educator:  June 19, 2014

Abstract

Purpose Inadequate literacy is common among patients with diabetes and may lead to adverse outcomes. The authors reviewed the relationship between literacy and health outcomes in patients with diabetes and potential interventions to improve outcomes.

Methods We reviewed 79 articles covering 3 key domains: (1) evaluation of screening tools to identify inadequate literacy and numeracy, (2) the relationships of a range of diabetes-related health outcomes with literacy and numeracy, and (3) interventions to reduce literacy-related differences in health outcomes. Read More

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