Efficacy and Safety of Dulaglutide Monotherapy Versus Metformin in Type 2 Diabetes in a Randomized Controlled Trial (AWARD-3)

Diabetes Care May 19, 2014

OBJECTIVE Compare the efficacy and safety of monotherapy with dulaglutide, a once-weekly GLP-1 receptor agonist, to metformin-treated patients with type 2 diabetes. The primary objective compared dulaglutide 1.5 mg and metformin on change from baseline glycosylated hemoglobin A1c (HbA1c) at 26 weeks.

RESEARCH DESIGN AND METHODS This 52-week double-blind study randomized patients to subcutaneous dulaglutide 1.5 mg, dulaglutide 0.75 mg, or metformin. Patients (N = 807) had HbA1c ≥6.5% (≥48 mmol/mol) and ≤9.5% (≤80 mmol/mol) with diet and exercise alone or low-dose oral antihyperglycemic medication (OAM) monotherapy; OAMs were discontinued at beginning of lead-in period. Read More

Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

JAMA: May 7, 2014

mportance  Despite concern about an “epidemic,” there are limited data on trends in prevalence of either type 1 or type 2 diabetes across US race and ethnic groups.

Objective  To estimate changes in the prevalence of type 1 and type 2 diabetes in US youth, by sex, age, and race/ethnicity between 2001 and 2009.

Design, Setting, and Participants  Case patients were ascertained in 4 geographic areas and 1 managed health care plan. The study population was determined by the 2001 and 2009 bridged-race intercensal population estimates for geographic sites and membership counts for the health plan.

Main Outcomes and Measures  Prevalence (per 1000) of physician-diagnosed type 1 diabetes in youth aged 0 through 19 years and type 2 diabetes in youth aged 10 through 19 years. Read More

Aging Americans fight diabetes differently

Tamhsc.edu: May 1, 2014

America is growing older and wider.  At the same time baby boomers (the population born between 1946 and 1964) are celebrating their 65thbirthdays, obesity rates in the United States are skyrocketing.  Seventy-five percent of Americans are currently living beyond the age of 65, which is great news.  But more than one-third of them (35.4 percent) are obese.

As the age and weight of the population increases, so does the prevalence of type 2 diabetes.  Nearly 27 percent of older adults have diabetes, compared with about 14 percent of individuals between the ages of 45 and 64. Read more

Glycemic index, glycemic load, and risk of type 2 diabetes: results from 3 large US cohorts and an updated meta-analysis1,2,3

Am J Clin Nutr: July 2014

Background: Epidemiologic evidence for the relation between carbohydrate quality and risk of type 2 diabetes (T2D) has been mixed.

Objective: We prospectively examined the association of dietary glycemic index (GI) and glycemic load (GL) with T2D risk. Read More

Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women

Springer: 4/26/14

Aims/hypothesis

Coffee and tea consumption has been associated with a lower type 2 diabetes risk but little is known about how changes in coffee and tea consumption influence subsequent type 2 diabetes risk. We examined the associations between 4 year changes in coffee and tea consumption and risk of type 2 diabetes in the subsequent 4 years. Read more

COMMENTARY: Diabetes in RGV is high, linked to depression, anxiety

The Monitor: Monday, April 21, 2014 12:15 am

DARLA KENDZOR, JOSEPH MCCORMICK, SUSAN FISHER-HOCH | Guest columnists

Diabetes is a significant public health issue in the Rio Grande Valley, especially for Mexican-Americans. Our own research at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health Brownsville Regional Campus has shown that 30 percent of Mexican-American adults who live near the U.S./Mexico border are diabetic, while the national average is 16.3 percent. Half of these border residents have not been diagnosed and two-thirds are not receiving treatment. Read More

Clinical Considerations for Insulin Pharmacotherapy in Ambulatory Care, Part One: Introduction and Review of Current Products and Guidelines

Clinical Diabetes: April 2014

This article describes available insulin products and published guidelines to aid clinicians in making treatment decisions for insulin-dependent patients with type 2 diabetes. It establishes the need for a thorough evaluation of the literature regarding ambulatory insulin dosing to further inform providers who manage insulin therapy for patients with type 2 diabetes. Read more

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