Effect of Glycemic Treatment and Microvascular Complications on Menopause in Women with Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Cohort

Objective We examined the impact of intensive vs. conventional diabetes treatment upon menopause among women with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT), a randomized controlled trial of intensive diabetes treatment, and its observational follow-up, the Epidemiology of Diabetes Interventions and Complications (EDIC) Study.

Research Design and Methods In a secondary analysis of women in DCCT/EDIC (n=657), outcomes were the cumulative incidences of natural menopause and surgical menopause. Cox regression analyses were used to examine associations with treatment group, time-varying estimates of hemoglobin A1c (HbA1c), insulin dosage, body mass index (BMI), and microvascular complications (retinopathy, nephropathy, and neuropathy). Read More