Earlier onset of complications in youth with type 2 diabetes

Objective To evaluate the risk of complications in youth with type 2 diabetes.

Research Design and Methods Population based cohorts of 342 prevalent youth (1-18 yrs) with type 2 diabetes, 1011 youth with type 1 diabetes and 1710 non-diabetes controls identified between 1986-2007 from a clinical registry and were linked to healthcare records to assess long-term outcomes utilizing ICD codes.

Results Youth with type 2 diabetes had an increased risk of any complication (HR 1.47; 95% CI 1.02-2.12). Significant adverse clinical factors included age at diagnosis (HR 1.08; 95% CI 1.02-2.12), HbA1c (HR 1.06; 95% CI 1.01-1.12) and, surprisingly, renin angiotensin aldosterone system (RAAS) inhibitor use (HR 1.75; 95% CI 1.27-2.41). HNF-1α G319S polymorphism was protective in the type 2 diabetes cohort (HR 0.58; 95% CI 0.34-0.99). Kaplan Meier statistics revealed an earlier diagnosis of renal and neurological complications in the type 2 diabetes cohort, manifesting within 5 years of diagnosis. Read More