Benefits and Harms of Treating Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research

Ann Intern Medicine: May 28, 2013

Background: Outcomes of treating gestational diabetes mellitus (GDM) are not well-established.

Purpose: To summarize evidence about the maternal and neonatal benefits and harms of treating GDM.

Data Sources: 15 electronic databases from 1995 to May 2012, gray literature, Web sites of relevant organizations, trial registries, and reference lists.

Study Selection: English-language randomized, controlled trials (n = 5) and cohort studies (n = 6) of women without known preexisting diabetes.

Data Extraction: One reviewer extracted data, and a second reviewer verified them. Two reviewers independently assessed methodological quality and evaluated strength of evidence for primary outcomes by using a Grading of Recommendations Assessment, Development and Evaluation approach.  Read more