Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus

Context: The stepwise hyperglycemic clamp procedure (SHCP) is the gold standard for measuring the renal threshold for glucose excretion (RT_G), but its use is limited to small studies in specialized laboratories.

Objective: The objective of the study was to validate a new method for determining RT_G using data obtained during a mixed-meal tolerance test (MMTT) in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus (T2DM).

Design: This was an open-label study with 2 sequential parts.

Setting: The study was performed at a single center in Germany.

Patients: Twenty-eight subjects with T2DM were studied. Read more