Albuminuria Associates With Calcified Atherosclerotic Plaque in African Americans With Diabetes
Minority Diabetes Reports Thursday, February 28th, 2013Diabetes Care: March 1, 2013
Relative to individuals with European ancestry, presence and severity of calcified atherosclerotic plaque (CP) are markedly lower in individuals with African ancestry (1,2). Factors potentially contributing to the ethnic variation in susceptibility to atherosclerosis include different relationships between CP and serum 25 hydroxyvitamin D concentrations and pericardial adipose tissue volumes in African Americans (AAs) relative to European Americans (EAs) (3,4). In addition, significant positive associations have been observed between CP and albuminuria in EAs with type 2 diabetes (5) but not AAs (419 subjects from 297 African American Diabetes Heart Study [AA-DHS] families) (6). Therefore, it remains unclear whether ethnic differences exist in the effect of albuminuria on risk for development and progression of CP. Read more
