Impaired Fasting Plasma Glucose and Type 2 Diabetes Are Related to the Risk of Out-of-Hospital Sudden Cardiac Death and All-Cause Mortality

ADA: December 17, 2012

OBJECTIVE The aim of the study was to determine whether impaired fasting plasma glucose (FPG) and type 2 diabetes may be risk factors for sudden cardiac death (SCD).

RESEARCH DESIGN AND METHODS This prospective study was based on 2,641 middle-aged men 42–60 years of age at baseline. Impaired FPG level (≥5.6 mmol/L) among nondiabetic subjects (501 men) was defined according to the established guidelines, and the group with type 2 diabetes included subjects (159 men) who were treated with oral hypoglycemic agents, insulin therapy, and/or diet. Read More

Health issues also affect Rio Grande Valley economy

The Brownsville Herald: By Melissa Montoya: Sunday, December 16, 2012

The serious threat of diabetes in the Rio Grande Valley could be harming more than just people’s health, officials say.

With studies that show diabetes affects 31 percent of the adult population in Brownsville, the economy is sure to suffer, said Joseph McCormick, the regional dean at the Brownsville Regional Campus for the University of Texas Health Science Center at Houston’s School of Public Health and vice president for South Texas Programs at the UT Health Science Center at San Antonio.

“Imagine how many people, thousands of those, each year are going to go to an emergency department with some complications of diabetes,” McCormick said. “Often it’s very late in the disease.”

In the United States, the cost associated with diabetes in 2007 was $174 billion, said Hasanat Alamgir, an associate professor at the UT School of Public Health, an expert in epidemiology and health economics. Of that amount, $116 billion goes directly toward medical expenditures, he said. For the same year, the estimated medical and indirect costs associated with diabetes for the Rio Grande Valley was $1.5 billion, according to the Brownsville Comprehensive Plan, which guides the development and future of the city. Read More

Health Care Costs in People With Diabetes and Their Association With Glycemic Control and Kidney Function

ADA: 12/13/12

OBJECTIVE To determine the association between laboratory-derived measures of glycemic control (HbA1c) and the presence of renal complications (measured by proteinuria and estimated glomerular filtration rate [eGFR]) with the 5-year costs of caring for people with diabetes.

RESEARCH DESIGN AND METHODS We estimated the cumulative 5-year cost of caring for people with diabetes using a province-wide cohort of adults with diabetes as of 1 May 2004. Costs included physician visits, hospitalizations, ambulatory care (emergency room visits, day surgery, and day medicine), and drug costs for people >65 years of age. Using linked laboratory and administrative clinical and costing data, we determined the association between baseline glycemic control (HbA1c), proteinuria, and kidney function (eGFR) and 5-year costs, controlling for age, socioeconomic status, duration of diabetes, and comorbid illness. Read More

Prevalence of Nonrefractive Visual Impairment in US Adults and Associated Risk Factors, 1999-2002 and 2005-2008

JAMA: December 12, 2012

Context  Over the past decade, chronic illnesses with ophthalmic sequelae such as diabetes and diabetic retinopathy have increased.

Objectives  To estimate prevalence of nonrefractive visual impairment and to describe its relationship with demographic and systemic risk factors including diagnosed diabetes.

Design, Setting, and Participants  The National Health and Nutrition Examination Survey (NHANES) examined a representative sample of the US noninstitutionalized population. In 1999-2002 and 2005-2008, 9471 and 10 480 participants aged 20 years or older received questionnaires, laboratory tests, and physical examinations. Visual acuity of less than 20/40 aided by autorefractor was classified as nonrefractive visual impairment.

Main Outcome Measure  Nonrefractive visual impairment. Read More

Incidence of diabetes among postmenopausal breast cancer survivors

Diabetologia: 12/10/12

Abstract: Aims/hypothesis Evidence is emerging of an association between breast cancer and diabetes; however, it is uncertain whether diabetes incidence is increased in postmenopausal breast cancer survivors compared with women without breast cancer. The objective of this study was to determine whether postmenopausal women who develop breast cancer have a higher incidence of diabetes than those who do not develop breast cancer.

Methods We used population-based data from Ontario, Canada to compare the incidence of diabetes among women with breast cancer, aged 55 years or older, from 1996 to 2008, with that of age-matched women without breast cancer.

We used Cox proportional hazard models to estimate the effect of breast cancer on the cause-specific hazard of developing diabetes overall and in the subgroup of women who received adjuvant chemotherapy.

Results Of 24,976 breast cancer survivors and 124,880 controls, 9.7% developed diabetes over a mean follow-up of 5.8 years. The risk of diabetes among breast cancer survivors compared with women without breast cancer began to increase 2 years after diagnosis (HR 1.07 [95% CI, 1.02, 1.12]), and rose to an HR of 1.21 (95% CI, 1.09, 1.35) after 10 years. Among those who received adjuvant chemotherapy (n04,404), risk was highest in the first 2 years after diagnosis (HR 1.24 [95% CI 1.12, 1.38]) and then declined. Conclusions/interpretation We found a modest increase in the incidence of diabetes among postmenopausal breast cancer survivors that varied over time. In most women the risk began to increase 2 years after cancer diagnosis but the highest risk was in the first 2 years in those who received adjuvant therapy. Our study suggests that greater diabetes screening and prevention strategies among breast cancer survivors may be warranted. Read More

Long-Term Exposure to Road Traffic Noise and Incident Diabetes: A Cohort Study

Ehp.niehs.nih.gov: December 10, 2012

Background: Road traffic noise at normal urban levels can lead to stress and sleep disturbances. Both excess of stress hormones and reduction in sleep quality and duration may lead to higher risk for type 2 diabetes.

Objective: To investigate whether long-term exposure to residential road traffic noise is associated with an increased risk of diabetes.

Methods: In the population-based Diet, Cancer and Health cohort of 57,053 people aged 50 to 64 years at enrollment in 1993-1997, we identified 3,869 cases of incident diabetes in a national diabetes registry between enrollment and 2006. The mean follow-up time was 9.6 years. Present and historical residential addresses from 1988 to 2006 were identified using a national register and exposure to road traffic noise was estimated for all addresses. Associations between exposure to road traffic noise and incident diabetes were analyzed in a Cox regression model. Read More

Racial/Ethnic Differences in the Prevalence of Proteinuric and Nonproteinuric Diabetic Kidney Disease

ADA: 12/13/12

OBJECTIVE To examine racial/ethnic differences in the prevalence of diabetic kidney disease (DKD), with and without proteinuria, in an outpatient health care organization.

RESEARCH DESIGN AND METHODS We examined electronic health records for 15,683 persons of non-Hispanic white (NHW), Asian (Asian Indian, Chinese, and Filipino), Hispanic, and non-Hispanic black (NHB) race/ethnicity with type 2 diabetes and no prior history of kidney disease from 2008 to 2010. We directly standardized age- and sex-adjusted prevalence rates of proteinuric DKD (proteinuria with or without low estimated glomerular filtration rate [eGFR]) or nonproteinuric DKD (low eGFR alone). We calculated sex-specific odds ratios (ORs) of DKD in racial/ethnic minorities (relative to NHWs) after adjustment for traditional DKD risk factors. Read More

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