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Thursday, August 30th, 2012
Care.diabetesjournals.org: August 24, 2012
Both stressful intrauterine milieus and genetic susceptibility have been linked to later-life diabetes risk. The current study aims to examine the interaction between low birth weight, a surrogate measure of stressful intrauterine milieus, and genetic susceptibility in relation to risk of type 2 diabetes in adulthood.
RESEARCH DESIGN AND METHODS The analysis included two independent, nested case-control studies of 2,591 type 2 diabetic case subjects and 3,052 healthy control subjects. We developed two genotype scores: an obesity genotype score based on 32 BMI-predisposing variants and a diabetes genotype score based on 35 diabetes-predisposing variants. Read More
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Thursday, August 30th, 2012
Care.diabetesjournals.org: August 21, 2012
OBJECTIVE To examine the longitudinal effects of medication nonadherence (MNA) on key costs and estimate potential savings from increased adherence using a novel methodology that accounts for shared correlation among cost categories.
RESEARCH DESIGN AND METHODS Veterans with type 2 diabetes (740,195) were followed from January 2002 until death, loss to follow-up, or December 2006. A novel multivariate, generalized, linear, mixed modeling approach was used to assess the differential effect of MNA, defined as medication possession ratio (MPR) ≥0.8 on healthcare costs. A sensitivity analysis was performed to assess potential cost savings at different MNA levels using the Consumer Price Index to adjust estimates to 2012 dollar value. Read more
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Thursday, August 30th, 2012
News.aces.illinois.edu: AUGUST 20, 2012
URBANA – In evaluating the bioactive compounds of Illinois blueberry and blackberry wines, University of Illinois scientists have found compounds that inhibit enzymes responsible for carbohydrate absorption and assimilation. And that could mean a tasty way to help people with diabetes decrease their blood sugar.
“We’re thinking about a dealcoholized fermented fruit beverage that would optimize the inhibition of the alpha-amylase and alpha-glucosidase enzymes and also make use of the wines’ other healthful bioactive components,” said Elvira de Mejia, a U of I professor of food chemistry and food toxicology.
Graduate student Michelle Johnson evaluated the nutritional value of 19 Illinois wines, deciding on a blueberry-blackberry blend for maximum effectiveness.
In the in vitro study, the scientists compared the anti-carb effects of the alpha-amylase and alpha-glucosidase enzymes with acarbose, an anti-diabetes drug. The carb-degrading enzymes were inhibited in a range of 91.8 percent for alpha-amylase compared to acarbose and 103.2 percent for alpha-glucosidase compared to acarbose, de Mejia said. read more
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Thursday, August 30th, 2012
Cdc.gov: 8/20/12
Make a plan to help your child manage diabetes at school. Start by meeting with school staff and by making sure your child has the necessary supplies for routine care and blood sugar emergencies.
You may already have bought the basic school supplies for sending your child back to school. But if your child has diabetes, you need to make additional preparations.
A person with diabetes must manage this chronic illness all the time, including during the school day. Staff such as nurses, teachers and coaches can work with you and your child on managing diabetes. This assistance may include helping your child take medications, check blood sugar levels, choose healthy foods in the cafeteria, and be physically active. Read More
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Thursday, August 30th, 2012
Ehp03.niehs.nih.gov: 8/10/12
Background: Diabetes affects an estimated 346 million people globally. Total deaths from diabetes are projected to increase > 50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This report is derived from discussions at that workshop.
Objectives: Our objective was to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes, and to identify data gaps and areas for future evaluation/research. The extent of the existing literature was insufficient to consider obesity as an outcome. Read More
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Minority Diabetes Reports
Thursday, August 30th, 2012
Care.diabetesjournals.org: September 2012 vol. 35no. 9 1951-1958
OBJECTIVE It has been postulated that the effectiveness of bariatric surgery varies between ethnic groups. However, data regarding this topic are inconclusive, as most studies included few patients from minority groups. We conducted a meta-analysis to determine the difference in percentage of excess weight loss (%EWL) 1–2 years after bariatric surgery in people of African and Caucasian descent. We also studied differences in diabetes mellitus (DM) remission.
RESEARCH DESIGN AND METHODS We performed a MEDLINE and EMBASE search for studies reporting %EWL and/or DM remission after bariatric surgery and including both African Americans and Caucasians. The 613 publications obtained were reviewed. We included 14 studies (1,087 African Americans and 2,714 Caucasians); all provided data on %EWL and 3 on DM remission. We extracted surgery type, %EWL, and DM remission 1–2 years after surgery. After analyzing %EWL for any surgery type, we performed subanalyses for malabsorptive and restrictive surgery. Read more
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Minority Diabetes Reports
Thursday, August 30th, 2012
Uthouston.edu: HOUSTON – (Aug. 24, 2012)
New study results call for better screening for diabetes, heart disease
Mexican-Americans with an ancestral link to Amerindian tribes were found to have higher insulin resistance levels, which is an indication of several chronic conditions such as type 2 diabetes, according to research by The University of Texas Health Science Center at Houston (UTHealth).
“Now that we have identified the ancestral link, we have an opportunity to develop some new approaches to personalized medicine using genetic markers,” said HuiQi Qu, Ph.D., the study’s lead author and assistant professor at The University of Texas School of Public Health Brownsville Regional Campus, part of UTHealth. Study results are published in the August issue of Diabetes Care, a journal of the American Diabetes Association.
The findings are part of a series of recent articles published in five journals by UTHealth researchers and colleagues that examine the testing, diagnosing and treating of chronic diseases in the Mexican- American population using data and blood samples from the Cameron County Hispanic Cohort (CCHC). Read more
