Posted by Staff
Clinical Trials
Thursday, June 28th, 2012
http://ctj.sagepub.com: June 22, 2012.
Background The role of the study coordinator (SC) in multicenter studies of long duration has received limited attention.
Purpose To describe the evolution of the SC’s role during the 28-year Diabetes Control and Complications Trial (DCCT) and its follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC) study.
Methods The evolution of the SC’s position from the traditional role of protocol implementation to that of research collaborator and co-investigator, based on personal experience and observation, is described in detail. Findings from a survey regarding professional demographics and job satisfaction, completed by all 28 SCs in 2010, provided additional information. We used dimensions of the SC’s role specific to DCCT/EDIC to construct a classification schema of functions and responsibilities that describe the SC’s role. Read more
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News
Friday, June 22nd, 2012
Businesswire.com: June 18, 2012 10:00 AM Eastern Daylight Time
COLLEGE STATION, Texas–(BUSINESS WIRE)–Peaches, plums and nectarines have bioactive compounds that can potentially fight-off obesity-related diabetes and cardiovascular disease, according to new studies by Texas AgriLife Research.
“bioactive compounds of a fruit have been shown to potentially work in different fronts against a disease.”
The study, which will be presented at the American Chemical Society in Philadelphia next August, showed that the compounds in stone fruits could be a weapon against “metabolic syndrome,” in which obesity and inflammation lead to serious health issues, according to Dr. Luis Cisneros-Zevallos, AgriLife Research food scientist.
“In recent years obesity has become a major concern in society due to the health problems associated to it,” said Cisneros-Zevallos, who also is an associate professor at Texas A&M University. “In the U.S., statistics show that around 30 percent of the population is overweight or obese, and these cases are increasing every year in alarming numbers.”
While he acknowledged that lifestyle, genetic predisposition and diet play a major role in one’s tendency toward obesity, “the major concern about obesity is the associated disease known as metabolic syndrome.
“Our studies have shown that stone fruits – peaches, plums and nectarines – have bioactive compounds that can potentially fight the syndrome,” Cisneros-Zevallos said. “Our work indicates that phenolic compounds present in these fruits have anti-obesity, anti-inflammatory and anti-diabetic properties in different cell lines and may also reduce the oxidation of bad cholesterol LDL which is associated to cardiovascular disease.”
What is unique to these fruits, he said, is that their mixture of the bioactive compounds work simultaneously within the different components of the disease. Read more
Posted by Staff
News
Friday, June 22nd, 2012
Diabetes Care June 14, 2012.
OBJECTIVE Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood. We examined the association of diabetes with cause-specific mortality, including deaths from specific cancers.
RESEARCH DESIGN AND METHODS A prospective cohort of 1,053,831 U.S. adults, without cancer at baseline, enrolled in the Cancer Prevention Study-II in 1982 and was followed for mortality until December 2008. At baseline, participants completed a self-administered questionnaire that included information on diabetes, smoking, physical activity, height, and weight. Multivariable-adjusted relative risks (RRs) (95% CI) were estimated using Cox proportional hazards regression. Read more
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News
Friday, June 22nd, 2012
Medicalnewstoday.com: Article Date: 14 Jun 2012 – 11:00 PDT
A new study has found that patients diagnosed with Type 2 diabetes are more likely to benefit in the long term if they receive ongoing and sustained clinical support instead of a one-off session when they are first diagnosed.
The study, published in British Medical Journal (BMJ), was conducted by Professor Kamlesh Khunti, of the University of Leicester, and Professor Melanie Davies, of the University of Leicester and Leicester hospitals, with colleagues from the Leicester Diabetes Center.
The researchers explained:
“In recent years, programs to educate people with Type 2 diabetes about self management have become the focus of attention among healthcare professionals and are advocated for people with the condition. Yet few established self management education programs have reported long term effects of the intervention.”
The researchers examined three year follow-up data on 731 individuals newly diagnosed with Type 2 diabetes from over 200 general practices. At the start of the study participants were randomly assigned to receive either a one-day self-management education program (DESMOND) or usual GP care. Read more
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News
Friday, June 22nd, 2012
Young adult experiences and relationship to glycemic control
Diabetes Care June 14, 2012
OBJECTIVE To examine characteristics of the transition from pediatric to adult care in emerging adults with type 1 diabetes and evaluate associations between transition characteristics and glycemic control.
RESEARCH DESIGN AND METHODS We developed and mailed a survey to evaluate the transition process in emerging adults with type 1 diabetes, aged 22 to 30 years, receiving adult diabetes care at a single center. Current A1C data were obtained from the medical record. Read more
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News
Friday, June 22nd, 2012
Diabetes Care: June 11, 2012.
OBJECTIVE To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk.
RESEARCH DESIGN AND METHODS Korean subjects (40–79 years) were enrolled (n= 7,233) through the National Health Insurance Corporation who were not diagnosed with diabetes at baseline. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice.
RESULTS During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabetes was positively associated with BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. Read more
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Minority Diabetes Reports
Friday, June 22nd, 2012
Diabetes Care June 14, 2012
OBJECTIVE HbA1c levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. This comparison has not been performed between South Asians (SAs) and WEs. We analyzed the independent effect of ethnicity on HbA1c and fasting and 2-h plasma glucose (FPG and 2hrPG, respectively) between these groups.
RESEARCH DESIGN AND METHODS Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance, HbA1c, and other risk factor measurements.
RESULTS Significant associations with HbA1c included ethnicity, FPG, 2hrPG, and homeostasis model assessment of β-cell function (P < 0.001); age and sex (P < 0.01); and fasting insulin and potassium (P < 0.05). After adjusting for these and other risk factors, SAs demonstrated higher HbA1c (6.22 and 6.02%, mean difference 0.20%, 0.10–0.30, P < 0.001), FPG (5.15 and 5.30 mmol/L, mean difference 0.15 mmol/L, 0.09–0.21, P < 0.001), and 2hrPG (5.82 and 6.57 mmol/L, mean difference 0.75 mmol/L, 0.59–0.92, P < 0.001) compared with WEs, respectively. Read more
