Poor Cognitive Function and Risk of Severe Hypoglycemia in Type 2 Diabetes
Clinical Trials Wednesday, March 7th, 2012Post hoc epidemiologic analysis of the ACCORD trial
Zubin Punthakee, MD, MSC1⇓, Michael E. Miller, PHD2, Lenore J. Launer, PHD3,Jeff D. Williamson, MD, MHS4, Ronald M. Lazar, PHD5, Tali Cukierman-Yaffee, MD, MSC6, Elizabeth R. Seaquist, MD7, Faramarz Ismail-Beigi, MD, PHD8,Mark D. Sullivan, MD, PHD9, Laura C. Lovato, MS10, Richard M. Bergenstal, MD11, Hertzel C. Gerstein, MD, MSC1 and for the ACCORD Group of Investigators and the ACCORD-MIND Investigators* February 28, 2012, doi:10.2337/dc11-1855.
Abstract
OBJECTIVE Self-management of type 2 diabetes including avoidance of hypoglycemia is complex, but the impact of cognition on safe self-management is not well understood. This study aimed to assess the effect of baseline cognitive function and cognitive decline on subsequent risk of severe hypoglycemia and to assess the effect of different glycemic strategies on these relationships.
RESEARCH DESIGN AND METHODS Prospective cohort analysis of data from the ACCORD trial included 2,956 adults aged ≥55 years with type 2 diabetes and additional cardiovascular risk factors. Cognitive tests (Digit Symbol Substitution Test [DSST], Rey Auditory Verbal Learning Test, Stroop Test, and Mini Mental Status Examination) were conducted at baseline and 20 months. Study outcomes were incident confirmed severe hypoglycemia requiring medical assistance (HMA) and hypoglycemia requiring any assistance (HAA). Read More
