Prevention of Diabetes With Mediterranean Diets: A Subgroup Analysis of a Randomized Trial

Annals: January 7, 2014

Background: Interventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated.

Objective: To assess the efficacy of Mediterranean diets for the primary prevention of diabetes in the Prevención con Dieta Mediterránea trial, from October 2003 to December 2010 (median follow-up, 4.1 years).

Design: Subgroup analysis of a multicenter, randomized trial. (Current Controlled Trials: ISRCTN35739639)

Setting: Primary care centers in Spain.

Participants: Men and women without diabetes (3541 patients aged 55 to 80 years) at high cardiovascular risk.

Intervention: Participants were randomly assigned and stratified by site, sex, and age but not diabetes status to receive 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil (EVOO), Mediterranean diet supplemented with nuts, or a control diet (advice on a low-fat diet). No intervention to increase physical activity or lose weight was included. Read More

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